Ketamine by Kenji Hashimoto & Soichiro Ide & Kazutaka Ikeda
Author:Kenji Hashimoto & Soichiro Ide & Kazutaka Ikeda
Language: eng
Format: epub
ISBN: 9789811529023
Publisher: Springer Singapore
Social withdrawal, one of the negative symptoms of schizophrenia, is induced by ketamine. Repeated administration of ketamine at a relatively high dose (30 mg/kg ip) in rats decreased social interaction; however, this effect was only evident in the nonaggressive component of social interaction (Becker and Grecksch 2004). This effect of ketamine was antagonized by clozapine but not by haloperidol. A similar dosing regimen also reduced social interaction and this effect was reversed by memantine, a modulator of the NMDA receptor (Uribe et al. 2013).
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